Fig. 6
- ID
- ZDB-FIG-240725-50
- Publication
- García-Poyatos et al., 2024 - Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization
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Metabolic rewiring in cox7a1−/− toward a pro-regenerative signature (A and B) Heatmap of proteins differentially expressed between cox7a1+/+ (WT) and cox7a1−/− associated to the mitochondrial respiratory chain (A) or different metabolic pathways (B) (p value < 0.05). Scale shows normalized expression levels. Numbers indicate that proteins had been also associated to other analyzed pathways, as described in Data S4 . (C) Metabolites detected by NMR spectroscopy in adult uninjured hearts or hearts collected 7 days postinjury (dpi). n = 3–5 technical replicates; each being a pool of n = 5 biological samples. ∗ p < 0.05. Graph shown on the left indicates mean and SD. Mean values are also shown as a heatmap (right). Scale indicates fold-change of each metabolite compared with uninjured wild-type (WT) control sibling. (D) Summary of observed metabolic rewiring. Red, enzymes/metabolites overexpressed or enriched in cox7a1−/− compared with uninjured control hearts. Blue, reduced enzymes/metabolites in cox7a1−/− compared with uninjured control hearts. |
Reprinted from Developmental Cell, 59(14), García-Poyatos, C., Arora, P., Calvo, E., Marques, I.J., Kirschke, N., Galardi-Castilla, M., Lembke, C., Meer, M., Fernández-Montes, P., Ernst, A., Haberthür, D., Hlushchuk, R., Vázquez, J., Vermathen, P., Enríquez, J.A., Mercader, N., Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization, 1824-1841.e10, Copyright (2024) with permission from Elsevier. Full text @ Dev. Cell