PUBLICATION
Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization
- Authors
- García-Poyatos, C., Arora, P., Calvo, E., Marques, I.J., Kirschke, N., Galardi-Castilla, M., Lembke, C., Meer, M., Fernández-Montes, P., Ernst, A., Haberthür, D., Hlushchuk, R., Vázquez, J., Vermathen, P., Enríquez, J.A., Mercader, N.
- ID
- ZDB-PUB-240505-3
- Date
- 2024
- Source
- Developmental Cell 59(14): 1824-1841.e10 (Journal)
- Registered Authors
- Marques, Ines, Mercader Huber, Nadia
- Keywords
- Ca(2+) signaling, cox7a1, cox7a2l, electron transport chain, heart regeneration, metabolic rewiring, mitochondria, muscle physiology, scaf1, supercomplex assembly, zebrafish
- Datasets
- GEO:GSE254466
- MeSH Terms
-
- Animals
- Electron Transport Complex IV*/genetics
- Electron Transport Complex IV*/metabolism
- Heart*/physiology
- Muscle, Skeletal*/metabolism
- Myocardium/metabolism
- Oxidative Phosphorylation*
- Protein Multimerization
- Regeneration*/physiology
- Zebrafish*/metabolism
- Zebrafish Proteins*/genetics
- Zebrafish Proteins*/metabolism
- PubMed
- 38701784 Full text @ Dev. Cell
Citation
García-Poyatos, C., Arora, P., Calvo, E., Marques, I.J., Kirschke, N., Galardi-Castilla, M., Lembke, C., Meer, M., Fernández-Montes, P., Ernst, A., Haberthür, D., Hlushchuk, R., Vázquez, J., Vermathen, P., Enríquez, J.A., Mercader, N. (2024) Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization. Developmental Cell. 59(14):1824-1841.e10.
Abstract
The oxidative phosphorylation (OXPHOS) system is intricately organized, with respiratory complexes forming super-assembled quaternary structures whose assembly mechanisms and physiological roles remain under investigation. Cox7a2l, also known as Scaf1, facilitates complex III and complex IV (CIII-CIV) super-assembly, enhancing energetic efficiency in various species. We examined the role of Cox7a1, another Cox7a family member, in supercomplex assembly and muscle physiology. Zebrafish lacking Cox7a1 exhibited reduced CIV2 formation, metabolic alterations, and non-pathological muscle performance decline. Additionally, cox7a1-/- hearts displayed a pro-regenerative metabolic profile, impacting cardiac regenerative response. The distinct phenotypic effects of cox7a1-/- and cox7a2l-/- underscore the diverse metabolic and physiological consequences of impaired supercomplex formation, emphasizing the significance of Cox7a1 in muscle maturation within the OXPHOS system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping