tricarboxylic acid cycle

Term ID

GO:0006099

Synonyms

• citric acid cycle
• Krebs cycle
• oxidative TCA cycle
• TCA cycle

Definition

A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. 0198506732

References

• MetaCyc:P105-PWY
• MetaCyc:PWY-5690
• MetaCyc:PWY-5913
• MetaCyc:PWY-6969
• MetaCyc:PWY-7254
• MetaCyc:PWY66-398
• MetaCyc:REDCITCYC
• MetaCyc:TCA
• MetaCyc:TCA-1
• Reactome:R-HSA-71403
• Wikipedia:Tricarboxylic_acid_cycle

Ontology

GO: Biological Process    QuickGO    AmiGO