FIGURE

Fig. 1

ID

ZDB-FIG-240605-69

Publication

Ye et al., 2022 - c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model

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Fig. 1

Both BCR/ABL1 and c-myb overexpression can up-regulate neutrophil-related genes. (A?L) Whole-mount in situ hybridization (WISH) showed increases in lyz (A?C), mpx (D?F), npsn (G?I), and srgn (J?L) expression in Tg(hsp70:p210BCR/ABL1) and c-mybhyper at 36 hpf compared with controls. Blue arrowheads indicated lyz+, mpx+, srgn+ and npsn+ neutrophils in each row. (M?P) Quantification of numbers of 36 hpf lyz+ (M) (sibling, n = 31; c-mybhyper, n = 30; Tg(hsp70:p210BCR/ABL1), n = 16), mpx+ (N) (sibling, n = 30; c-mybhyper, n = 30; Tg(hsp70:p210BCR/ABL1), n = 15), npsn+ (O) (sibling, n = 32; c-mybhyper, n = 32; Tg(hsp70:p210BCR/ABL1), n = 22), srgn+ (P) (sibling, n = 31; c-mybhyper, n = 32; Tg(hsp70:p210BCR/ABL1), n = 14) cells. Scale bar, 200 ?m; applies to panels (A?L).

Expression Data

Genes:	lyz mpx npsn srgn
Fish:	AB zf169Tg (AB) zf3346Tg (AB)
Condition:	heat shock
Anatomical Term:	neutrophil
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf169Tg (AB) zf3346Tg (AB)
Condition:	heat shock
Observed In:	neutrophil
Stage:	Prim-25

Phenotype Detail

Acknowledgments

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