FIGURE

Fig. 1

ID

ZDB-FIG-240605-69

Publication

Ye et al., 2022 - c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

Both BCR/ABL1 and c-myb overexpression can up-regulate neutrophil-related genes. (A–L) Whole-mount in situ hybridization (WISH) showed increases in lyz (A–C), mpx (D–F), npsn (G–I), and srgn (J–L) expression in Tg(hsp70:p210BCR/ABL1) and c-mybhyper at 36 hpf compared with controls. Blue arrowheads indicated lyz+, mpx+, srgn+ and npsn+ neutrophils in each row. (M–P) Quantification of numbers of 36 hpf lyz+ (M) (sibling, n = 31; c-mybhyper, n = 30; Tg(hsp70:p210BCR/ABL1), n = 16), mpx+ (N) (sibling, n = 30; c-mybhyper, n = 30; Tg(hsp70:p210BCR/ABL1), n = 15), npsn+ (O) (sibling, n = 32; c-mybhyper, n = 32; Tg(hsp70:p210BCR/ABL1), n = 22), srgn+ (P) (sibling, n = 31; c-mybhyper, n = 32; Tg(hsp70:p210BCR/ABL1), n = 14) cells. Scale bar, 200 μm; applies to panels (A–L).

Expression Data

Genes:	lyz mpx npsn srgn
Fish:	AB zf169Tg (AB) zf3346Tg (AB)
Condition:	heat shock
Anatomical Term:	neutrophil
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf169Tg (AB) zf3346Tg (AB)
Condition:	heat shock
Observed In:	neutrophil
Stage:	Prim-25

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Animal Model Exp Med