Gene
npsn
- ID
- ZDB-GENE-040420-2
- Name
- nephrosin
- Symbol
- npsn Nomenclature History
- Previous Names
-
- npsnl
- ZC6AST2 (1)
- zgc:110470
- zgc:152831
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Acts upstream of or within defense response to bacterium. Is expressed in hematopoietic cell and hematopoietic system.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Di et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12159 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15667 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34128 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40960 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sm15 | Allele with one deletion | Exon 5 | Frameshift | CRISPR | |
| sm16 | Allele with one insertion | Exon 6 | Frameshift | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-npsn | Di et al., 2017 | |
| MO1-npsn | N/A | Zhang et al., 2008 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Hatching enzyme, peptidase domain | Metallopeptidase, catalytic domain superfamily | Peptidase M12A | Peptidase, metallopeptidase |
|---|---|---|---|---|---|---|
| UniProtKB:Q05AP0 | InterPro | 274 | ||||
| UniProtKB:F1REP3 | InterPro | 280 | ||||
| UniProtKB:E9QE40 | InterPro | 272 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:MYC-npsn) |
|
| 1 | Di et al., 2017 | |
| Tg(npsn:EGFP) |
|
| 1 | Di et al., 2017 | |
| Tg(npsn:GFP) |
|
| 1 | Zebrafish Nomenclature Committee |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-150L7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110470 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152831 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158184 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192017 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077779 (1) | 1367 nt | ||
| Genomic | GenBank:BX957297 (1) | 79980 nt | ||
| Polypeptide | UniProtKB:F1REP3 (2) | 280 aa |
No data available
- Ye, Y., Yang, X., Li, F., Liu, W., Zhang, W., Huang, Z. (2022) c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model. Animal models and experimental medicine. 7(2):136-144
- Huang, Z., Chen, K., Chi, Y., Jin, H., Li, L., Zhang, W., Xu, J., Zhang, Y. (2021) Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb. The Journal of biological chemistry. 296:100272
- Yu, S.H., Zhu, K.Y., Zhang, F., Wang, J., Yuan, H., Chen, Y., Jin, Y., Dong, M., Wang, L., Jia, X.E., Gao, L., Dong, Z.W., Ren, C.G., Chen, L.T., Huang, Q.H., Deng, M., Zon, L.I., Zhou, Y., Zhu, J., Xu, P.F., Liu, T.X. (2018) The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochimica et biophysica acta. 1861(2):106-116
- Di, Q., Lin, Q., Huang, Z., Chi, Y., Chen, X., Zhang, W., Zhang, Y. (2017) Zebrafish nephrosin helps host defence against Escherichia coli infection.. Open Biology. 7(8)
- Lin, Q., Fan, S., Zhang, Y., Xu, M., Zhang, H., Yang, Y., Lee, A.P., Woltering, J.M., Ravi, V., Gunter, H.M., Luo, W., Gao, Z., Lim, Z.W., Qin, G., Schneider, R.F., Wang, X., Xiong, P., Li, G., Wang, K., Min, J., Zhang, C., Qiu, Y., Bai, J., He, W., Bian, C., Zhang, X., Shan, D., Qu, H., Sun, Y., Gao, Q., Huang, L., Shi, Q., Meyer, A., Venkatesh, B. (2016) The seahorse genome and the evolution of its specialized morphology. Nature. 540:395-399
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Murayama, E., Sarris, M., Redd, M., Le Guyader, D., Vivier, C., Horsley, W., Trede, N., Herbomel, P. (2015) NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation. Nature communications. 6:8375
- Patil, P., Uechi, T., Kenmochi, N. (2015) Incomplete splicing of neutrophil-specific genes affects neutrophil development in a zebrafish model of poikiloderma with neutropenia. RNA Biology. 12:426-434
- Wang, K., Fang, X., Ma, N., Lin, Q., Huang, Z., Liu, W., Xu, M., Chen, X., Zhang, W., Zhang, Y. (2015) Myeloperoxidase-deficient Zebrafish show an Augmented Inflammatory Response to Challenge with Candida albicans. Fish & shellfish immunology. 44(1):109-16
- Dong, Z.W., Ren, C.G., Xia, Y., Su, D., Du, T.T., Fan, H.B., Yuan, H., Wang, L., Dong, M., Li, W.C., Jin, Y., Chen, Y., Deng, M., Liu, T.X., Gu, A.H., Zhou, Y. (2014) Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. Journal of Hematology & Oncology. 7:17
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