Fig. 1
- ID
- ZDB-IMAGE-240605-68
- Genes
- Publication
- Ye et al., 2022 - c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model
- All Figures
- Figures for Ye et al., 2022
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Fig. 1 Both BCR/ABL1 and c-myb overexpression can up-regulate neutrophil-related genes. (A–L) Whole-mount in situ hybridization (WISH) showed increases in lyz (A–C), mpx (D–F), npsn (G–I), and srgn (J–L) expression in Tg(hsp70:p210BCR/ABL1) and c-mybhyper at 36 hpf compared with controls. Blue arrowheads indicated lyz+, mpx+, srgn+ and npsn+ neutrophils in each row. (M–P) Quantification of numbers of 36 hpf lyz+ (M) (sibling, n = 31; c-mybhyper, n = 30; Tg(hsp70:p210BCR/ABL1), n = 16), mpx+ (N) (sibling, n = 30; c-mybhyper, n = 30; Tg(hsp70:p210BCR/ABL1), n = 15), npsn+ (O) (sibling, n = 32; c-mybhyper, n = 32; Tg(hsp70:p210BCR/ABL1), n = 22), srgn+ (P) (sibling, n = 31; c-mybhyper, n = 32; Tg(hsp70:p210BCR/ABL1), n = 14) cells. Scale bar, 200 μm; applies to panels (A–L).