ZFIN ID: ZDB-GENE-020515-2
Gene Name: lysozyme
Gene Symbol: lyz    Nomenclature History

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Previous Names: lys C (1), lysozyme C (1), zgc:136734

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have lysozyme activity. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; pleuroperitoneal region; and posterior cardinal vein. Human ortholog(s) of this gene implicated in familial visceral amyloidosis. Orthologous to several human genes including LYZL1 (lysozyme like 1).
Genome Resources: Alliance (1),  Gene:677744 (1),  Ensembl(GRCz11):ENSDARG00000057789 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH lyz HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial visceral amyloidosis Alliance Amyloidosis, renal 105200
DISEASE ASSOCIATED WITH lyz VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Molecular Function lysozyme activity (more)
GO Terms (all 1)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA lyz-201 (1)    Ensembl 603
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM lyz
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-2.4lyz:EGFP) lyz EGFP Danio rerio 4 6
Tg(-4.1lyz:EGFP) lyz EGFP Danio rerio 1 15
Tg(lyz:akt2-EGFP) lyz akt2EGFP Danio rerio 1 4
tg(lyz:bfp) lyz BFP Danio rerio 1 3
tg(lyz:cxcr1-tagrfp-sfgfp) lyz cxcr1GFPTagRFP Danio rerio 1 1
tg(lyz:cxcr2-tagrfp-sfgfp) lyz cxcr2GFPTagRFP Danio rerio 1 1
Tg(lyz:Dendra2) lyz Dendra2 Danio rerio 1 2
Tg(lyz:DsRed2) lyz DsRed2 Danio rerio 1 141
Tg(lyz:EGFP) lyz EGFP Danio rerio 1 78
Tg(lyz:EGFP-Mmu.Rpl10a) lyz EGFP Danio rerioMus musculus 1 5
Tg(lyz:GAL4-VP16) lyz GAL4VP16 Danio rerio 1 6
Tg(lyz:GAL4-VP16,cryaa:CFP) cryaalyz CFPGAL4VP16 Danio rerio 1 1
Tg(lyz:GCaMP3) lyz GCaMP Danio rerio 2 1
Tg(lyz:GCaMP3-mKate2) lyz GCaMPmKate2 Danio rerio 1 2
Tg(lyz:H2B-mCherry) lyz mCherry Danio rerio 1 5
tg(lyz:hsa.mpo-emgfp,myl7:egfp) lyzmyl7 EGFPemGFP Danio rerioHomo sapiens 1 1
Tg(lyz:hsp70.3,EGFP) lyz EGFPhsp70.3 Danio rerio 1 2
Tg(lyz:hspb1,mCherry) lyz hspb1mCherry Danio rerio 1 2
Tg(lyz:HyPer) lyz HyPer Danio rerio 1 3
tg(lyz:kalta4,he1.1:bfp2) he1.1lyz BFPKALTA4 Danio rerio 1 1
Tg(lyz:lta4h-2A-mCherry) lyz 2Alta4hmCherry Danio rerio 1 2
Tg(lyz:LY-mKate2) lyz LYmKate2 Danio rerio 1 1
Tg(lyz:MA-mKate2) lyz MAmKate2 Danio rerio 1 2
tg(lyz:mcherry-2a-cdk2) lyz 2Acdk2mCherry Danio rerio 1 1
tg(lyz:mcherry-2a-cdk2_d145n) lyz 2Acdk2mCherry Danio rerio 1 1
tg(lyz:mir199-3a-dendra2) lyz Dendra2mir199-3a Danio rerio 1 1
Tg(lyz:mir722-Dendra2) lyz Dendra2mir722 Danio rerio 1 1
Tg(lyz:MITO-Dendra2) lyz Dendra2MITO Danio rerio 1 1
Tg(lyz:NLS-zCas9-2A-mCherry,rnu6-32:CRISPR1-polg) lyzrnu6-32 2ACRISPR1-polgmCherryNLSzCas9 Danio rerio 1 1
Tg(lyz:NLS-zCas9-NLS-mCherry,rnu6-32:control) lyzrnu6-32 mCherryNLSzCas9 Danio rerio 1 1
Tg(lyz:NTR,lanYFP) lyz NTRYFP Danio rerio 1 2
tg(lyz:ntr-mcherry) lyz mCherryNTR Danio rerio 1 1
Tg(lyz:RFP) lyz RFP Danio rerio 1 1
Tg(lyz:RFP-mir223) lyz mir223RFP Danio rerio 1 1
Tg(lyz:Rno.TRPV1-Tomato) lyz Tomato Danio rerioRattus norvegicus 0 1
Tg(lyz:tagGFP-YVAD-TagRFP) lyz GFPtagTagRFP Danio rerio 1 1
Tg(lyz:TagRFP) lyz TagRFP Danio rerio 1 4
Tg(lyz:xbp1,EGFP) lyz EGFPxbp1 Danio rerio 1 2
tg2(lyz:egfp) lyz EGFP Danio rerio 1 1
MARKER RELATIONSHIPS
lyz Contained in: [BAC] CH211-80N22 (1)
lyz Encodes: [cDNA] MGC:136734 (1), MGC:194008 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_139180 (1) 596 nt
Genomic GenBank:CT574587 (1) 160942 nt
Select Tool
Polypeptide UniProtKB:A0A2R8RWI8 (1) 151 aa
Sequence Information (all 19)
ORTHOLOGY for lyz ( Chr: 24 )
CITATIONS (205)