FIGURE

Fig. 4

ID

ZDB-FIG-240605-72

Publication

Ye et al., 2022 - c-myb is involved in CML progression and is a therapeutic target in the zebrafish CML model

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Fig. 4

Combined treatment with flavopiridol and imatinib had a better response in Tg(hsp70:p210BCR/ABL1);c-mybhyper. (A?H) WISH of lcp1 expression in the drug-treated larvae at 4.5 dpf. After heat shock treatment, 2.5 dpf Tg(hsp70:p210BCR/ABL1) and Tg(hsp70:p210BCR/ABL1);c-mybhyper were treated for 48 h with 1? DMSO control, 0.1 ?mol/L flavopiridol, 80 ?mol/L imatinib, or 0.1 ?mol/L flavopiridol combined with 80 ?mol/L imatinib. (I), Quantification of numbers of 4.5 dpf lcp1+ cells in CHT (Tg(hsp70:p210BCR/ABL1) DMSO, n = 30; Tg(hsp70:p210BCR/ABL1) imatinib, n = 29; Tg(hsp70:p210BCR/ABL1) flavopiridol, n = 30; Tg(hsp70:p210BCR/ABL1) flavopiridol+imatinib, n = 29; Tg(hsp70:p210BCR/ABL1);c-mybhyper DMSO, n = 30; Tg(hsp70:p210BCR/ABL1);c-mybhyper imatinib, n = 31; Tg(hsp70:p210BCR/ABL1);c-mybhyper flavopiridol, n = 30; Tg(hsp70:p210BCR/ABL1);c-mybhyper flavopiridol+imatinib, n = 27). Scale bar, 100 ?m; applies to panels (A?H).

Expression Data

Gene:	lcp1
Fish:	zf3346Tg (AB) zf169Tg; zf3346Tg (AB)
Conditions:	chemical treatment by environment: alvocidib, heat shock heat shock chemical treatment by environment: imatinib, heat shock chemical treatment by environment: imatinib, heat shock
Anatomical Term:	caudal hematopoietic tissue myeloid cell
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	zf3346Tg (AB) zf169Tg; zf3346Tg (AB)
Conditions:	chemical treatment by environment: alvocidib, heat shock heat shock chemical treatment by environment: imatinib, heat shock chemical treatment by environment: imatinib, heat shock
Observed In:	caudal hematopoietic tissue myeloid cell
Stage:	Day 4

Phenotype Detail

Acknowledgments

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