FIGURE

Fig. 2

ID

ZDB-FIG-240529-51

Publication

Sun et al., 2024 - ptx3a⁺ fibroblast/epicardial cells provide a transient macrophage niche to promote heart regeneration

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Fig. 2

Fb/Epi cells associate with macrophages and are required for macrophage recruitment during heart regeneration (A) Section images of ventricles from uninjured and injured tcf21:mCherry;mpeg:EGFP fish at 7 dpa for macrophage detection. Dashed box area is enlarged to the right. Dashed line indicates the amputation plane. Arrows represent mpeg+ macrophages associated with mCherry+ cells. n = 5. Scale bar, 50 μm. (B) Histological visualization of macrophages with or without epicardial cells in the injury site at 7 dpa, assessed for mpeg+ cells in injured ventricles from tcf21:NTR;mpeg:EGFP animals, and treated with vehicle (n = 7) or metronidazole (Mtz) (n = 6). Dashed line indicates the amputation plane. Brackets represent the wound. Scale bar, 50 μm. (C) Quantification of mpeg+ macrophages in the wound from (B). The experiments were repeated once. Mann-Whitney rank-sum test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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