Fig. 7

BiP inhibition rescues muscle function in DMD. (A–C) Representative birefringence images of 6 dpf DMSO-treated dmd+/+ and dmd–/– larvae and HM03-treated dmd–/– larvae. (D) Quantification of normalized birefringence intensity, which is the mean birefringence intensity relative to area, in 6 dpf DMSO- or HM03-treated dmd+/+ and dmd–/– larvae, as analyzed using a 2-way ANOVA with Šidák’s multiple correction post hoc test. Data are shown as mean ± SD. (E) Average speed, in mm/s, of 6 dpf DMSO- or HM03-treated dmd+/+ and dmd–/– larvae. Data are shown as mean ± SEM for 3–4 biological replicates and were analyzed using a 2-way ANOVA with Šidák’s multiple correction post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. All experiments performed in triplicate with the total number of fish examined in each replicate being documented in Supplemental Table 2.