FIGURE

Fig. 1

ID
ZDB-FIG-240524-53
Publication
Seliwjorstow et al., 2024 - Reversible Influence of Hemipiperazine Photochromism on the Early Development of Zebrafish Embryo
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Fig. 1

The Effect of Plinabulin Photoisomerization on Zebrafish Embryos. Plinabulin 1 inhibits microtubule dynamics, and can be photoisomerized between two thermally (meta)stable isomers with different activities. Here, we use 1 to reversibly control the epiboly in zebrafish embryos. The mitotic arrest caused by accumulation of the more toxic Z-1 can be reversed with light, before irreversible apoptosis takes place leading to embryos’ death.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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