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Fig. 1 The Effect of Plinabulin Photoisomerization on Zebrafish Embryos. Plinabulin 1 inhibits microtubule dynamics, and can be photoisomerized between two thermally (meta)stable isomers with different activities. Here, we use 1 to reversibly control the epiboly in zebrafish embryos. The mitotic arrest caused by accumulation of the more toxic Z-1 can be reversed with light, before irreversible apoptosis takes place leading to embryos’ death.
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