FIGURE

Fig. 1

ID

ZDB-FIG-240521-24

Publication

Chakraborty et al., 2024 - Inhibition of NF-κB-Mediated Proinflammatory Transcription by Ru(II) Complexes of Anti-Angiogenic Ligands in Triple-Negative Breast Cancer

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Fig. 1

Model diagram for the consequences of activation of NF-κB, a pivotal mediator of inflammation. On the right side, the diagram shows various diseases whose pathogenesis is related to the pivotal role of NF-κB. NF-κB being an inducible transcription factor can activate transcription of genes regulating inflammation, increasing the production of inflammatory cytokines, chemokines, adhesion molecules, proliferation, morphogenesis, differentiation, and angiogenesis. The left side of the diagram showcases few selective outcomes of chemotherapy-induced activation of NF-κB leading to drug resistance, endothelial cell autophagy, and enhanced permeability and apoptosis of cardiac cell damage.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Med. Chem.