ZFIN Image: Chakraborty et al., 2024, Fig. 1

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Figure Caption

Fig. 1 Model diagram for the consequences of activation of NF-κB, a pivotal mediator of inflammation. On the right side, the diagram shows various diseases whose pathogenesis is related to the pivotal role of NF-κB. NF-κB being an inducible transcription factor can activate transcription of genes regulating inflammation, increasing the production of inflammatory cytokines, chemokines, adhesion molecules, proliferation, morphogenesis, differentiation, and angiogenesis. The left side of the diagram showcases few selective outcomes of chemotherapy-induced activation of NF-κB leading to drug resistance, endothelial cell autophagy, and enhanced permeability and apoptosis of cardiac cell damage.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Med. Chem.