FIGURE

Fig. 1

ID

ZDB-FIG-240517-27

Publication

Zhu et al., 2024 - Allelic heterogeneity of TTNtv cardiomyopathy can be modeled in adult zebrafish

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Fig. 1

AH in cardiac function and sarcomere structure is noted in homozygous ttntv embryos. (A) Schematics of the ttntv mutants. These mutants have been generated previously (33). * indicates the location of truncation mutations. (B) Quantification of fractional shortening in the embryonic hearts at 2 dpf. *P < 0.0001. (C) Quantification of fractional shortening in the embryonic hearts at 9 dpf. (D) Comparison of cardiac sarcomere structure in 2 dpf embryos via F59 antibody staining. Scale bar = 20 μm. Insets show enlarged images of the area enclosed with dashed lines. Scale bar = 5 μm. Arrowheads indicate sarcomeres with striated patterns. Arrows indicate immature sarcomeres with less striated patterns.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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