FIGURE

Fig. 2.

ID

ZDB-FIG-240211-49

Publication

Torraca et al., 2023 - Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri

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Fig. 2.

Analysis of differentially expressed genes in S. flexneri-injected embryos. (A,B) Volcano plots of differentially expressed genes between embryos infected with S. flexneri and mock-injected at 6 hpi (A) and 24 hpi (B). Each point represents a gene, -log₁₀(adjusted P value) is plotted on the y-axis and log₂(fold change) on the x-axis. Upregulated genes are coloured in orange and downregulated genes in blue. Genes with the highest -log₁₀(adjusted P value) are labelled. gpr84 and acod1 are highlighted in black as these genes were further pursued for functional characterisation for a role in susceptibility to infection. (C) Gene ontology (GO) term enrichments. Network diagrams of GO term enrichments for genes differentially expressed at 6 hpi only (left), 24 hpi only (right) and both 6 and 24 hpi (middle). Each node in the diagrams represents an enriched GO term, and terms are connected to terms that share annotated genes. This clusters the terms into process-related groups. The Venn diagram shows the numbers of differentially expressed genes at each timepoint and the overlap.

Expression Data

Genes:	c9 cp cxcl18b fn1b il6st il34 irf1b mxc psme2 rgs4 sele serpinh1b (all 12)
Fish:	AB
Condition:	bacterial treatment by injection: Shigella flexneri
Anatomical Term:	whole organism
Stage Range:	Long-pec to Pec-fin

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	bacterial treatment by injection: Shigella flexneri
Observed In:	antigen processing and presentation of endogenous peptide antigen via MHC class I apoptotic process cholesterol transport epiboly fatty acid metabolic process inflammatory response mitotic nuclear division NAD DNA ADP-ribosyltransferase activity nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway proton-transporting ATP synthase complex assembly regulation of ATP-dependent activity regulation of catalytic activity regulation of oxidoreductase activity response to lipid response to oxidative stress response to virus response to wounding superoxide-generating NADPH oxidase activity whole organism xenobiotic metabolic process (all 20)
Stage Range:	Long-pec to Pec-fin

Phenotype Detail

Acknowledgments

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