Gene
fn1b
- ID
- ZDB-GENE-030131-6545
- Name
- fibronectin 1b
- Symbol
- fn1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity and proteoglycan binding activity. Acts upstream of or within atrioventricular valve morphogenesis; heart field specification; and somitogenesis. Predicted to be located in extracellular space. Is expressed in several structures, including fin; heart; integument; mesoderm; and musculature system. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1057 (24 images)
- IMAGE:7160327 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Steed et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylometaphyseal dysplasia corner fracture type | Alliance | Spondylometaphyseal dysplasia, corner fracture type | 184255 |
| Glomerulopathy with fibronectin deposits 2 | 601894 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000083 | Fibronectin, type I |
| Domain | IPR000562 | Fibronectin type II domain |
| Domain | IPR003961 | Fibronectin type III |
| Family | IPR050991 | Extracellular Matrix Regulatory Proteins |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036943 | Fibronectin type II domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Extracellular Matrix Regulatory Proteins | Fibronectin, type I | Fibronectin type II domain | Fibronectin type II domain superfamily | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Kringle-like fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6JAN2 | InterPro | 2408 | ||||||||
| UniProtKB:A0A8M2B744 | InterPro | 2407 | ||||||||
| UniProtKB:A2CEW3 | InterPro | 2500 |
Interactions and Pathways
No data available
Plasmids
No data available