Gene
fn1b
- ID
- ZDB-GENE-030131-6545
- Name
- fibronectin 1b
- Symbol
- fn1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity and proteoglycan binding activity. Acts upstream of or within atrioventricular valve morphogenesis; heart field specification; and somitogenesis. Predicted to be located in extracellular space. Is expressed in several structures, including fin; heart; integument; mesoderm; and musculature system. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1057 (24 images)
- IMAGE:7160327 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Steed et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013676Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa553 | Allele with one point mutation | Exon 1 | Premature Stop | ENU | |
| sa19407 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19408 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39535 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ya14Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| ya16Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| zko98a | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fn1b | (3) | |
| CRISPR2-fn1b | (2) | |
| CRISPR3-fn1b | Sun et al., 2019 | |
| MO1-fn1b | N/A | (9) |
| MO2-fn1b | N/A | (9) |
| MO3-fn1b | N/A | Steed et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylometaphyseal dysplasia corner fracture type | Alliance | Spondylometaphyseal dysplasia, corner fracture type | 184255 |
| Glomerulopathy with fibronectin deposits 2 | 601894 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Extracellular Matrix Regulatory Proteins | Fibronectin, type I | Fibronectin type II domain | Fibronectin type II domain superfamily | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Kringle-like fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6JAN2 | InterPro | 2408 | ||||||||
| UniProtKB:A0A8M2B744 | InterPro | 2407 | ||||||||
| UniProtKB:A2CEW3 | InterPro | 2500 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1.8-fn1b:EGFP,cryaa:EGFP) |
|
| 1 | Tamaki et al., 2023 | |
| Tg(-3.2fn1b:EGFP,cryaa:EGFP) |
|
| 1 | Tamaki et al., 2023 | |
| Tg(-4.5fn1b:EGFP,cryaa:EGFP) |
|
| 1 | Tamaki et al., 2023 | |
| Tg(fn1b:Cre-ERT2,cryaa:EGFP) |
|
| 1 | Shibata et al., 2018 | |
| Tg(fn1b:EGFP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-4O17 | ZFIN Curated Data | |
| Contained in | BAC | CH211-172N16 | ZFIN Curated Data | |
| Contains | SNP | rs3727479 | ZFIN Curated Data | |
| Contains | SNP | rs3727480 | ZFIN Curated Data | |
| Contains | SNP | rs3727481 | ZFIN Curated Data | |
| Contains | SNP | rs3727482 | ZFIN Curated Data | |
| Contains | SNP | rs3727483 | ZFIN Curated Data | |
| Contains | SNP | rs3727484 | ZFIN Curated Data | |
| Encodes | EST | cb1057 | Thisse et al., 2001 | |
| Encodes | EST | fa14f11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013261 (1) | 8254 nt | ||
| Genomic | GenBank:CR762428 (2) | 140219 nt | ||
| Polypeptide | UniProtKB:A2CEW3 (1) | 2500 aa |
- She, P., Gao, B., Li, D., Wu, C., Zhu, X., He, Y., Mo, F., Qi, Y., Jin, D., Chen, Y., Zhao, X., Lin, J., Hu, H., Li, J., Zhang, B., Xie, P., Lin, C., Christoffels, V.M., Wu, Y., Zhu, P., Zhong, T.P. (2025) The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis. Nature communications. 16:232232
- Bhattarai, P., Gunasekaran, T.I., Belloy, M.E., Reyes-Dumeyer, D., Jülich, D., Tayran, H., Yilmaz, E., Flaherty, D., Turgutalp, B., Sukumar, G., Alba, C., McGrath, E.M., Hupalo, D.N., Bacikova, D., Le Guen, Y., Lantigua, R., Medrano, M., Rivera, D., Recio, P., Nuriel, T., Ertekin-Taner, N., Teich, A.F., Dickson, D.W., Holley, S., Greicius, M., Dalgard, C.L., Zody, M., Mayeux, R., Kizil, C., Vardarajan, B.N. (2024) Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease. Acta Neuropathologica. 147:7070
- Carver, J.J., Amato, C.M., Yao, H., Zhu, Y. (2024) Adamts9 is required for the development of primary ovarian follicles and maintenance of female sex in zebrafish. Biology of reproduction. 111(5):1107-1128
- Jülich, D., Holley, S.A. (2024) Live imaging of Fibronectin 1a-mNeonGreen and Fibronectin 1b-mCherry knock-in alleles during early zebrafish development. Cells & development. 177:203900
- Xiao, G., Li, X., Yang, H., Zhang, R., Huang, J., Tian, Y., Nie, M., Sun, X. (2024) mTOR mutation disrupts larval zebrafish tail fin regeneration via regulating proliferation of blastema cells and mitochondrial functions. Journal of orthopaedic surgery and research. 19:321321
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Gafranek, J.T., D'Aniello, E., Ravisankar, P., Thakkar, K., Vagnozzi, R.J., Lim, H.W., Salomonis, N., Waxman, J.S. (2023) Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart. Nature communications. 14:55095509
- Hipke, K., Pitter, B., Hruscha, A., van Bebber, F., Modic, M., Bansal, V., Lewandowski, S.A., Orozco, D., Edbauer, D., Bonn, S., Haass, C., Pohl, U., Montanez, E., Schmid, B. (2023) Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. Frontiers in cell and developmental biology. 11:11699621169962
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Tamaki, T., Yoshida, T., Shibata, E., Nishihara, H., Ochi, H., Kawakami, A. (2023) Splashed E-box and AP-1 motifs cooperatively drive regeneration response and shape regeneration abilities. Biology Open. 12(2):
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