FIGURE

Fig. 17

ID

ZDB-FIG-240130-33

Publication

Mi et al., 2023 - Stimulation of liver fibrosis by N2 neutrophils in Wilson's disease

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Fig. 17

STAT3 is highly increased in liver neutrophils in ATP7B-KO mice. (A) Formalin-fixed mouse liver tissue sections from STATTIC-treated or vehicle-treated wild-type and ATP7B-KO mice were subjected to immunofluorescence staining of anti-pSTAT3 and anti-Ly6G. Representative images of pSTAT3 (green), Ly6G (red), and nuclei (blue) are shown. Arrows indicate pSTAT3-positive liver neutrophils. Scale bar: 40 μm. (B) qPCR of mRNA levels of Stat3 in liver neutrophils isolated from wild-type and ATP7B-KO mice upon STATTIC or vehicle treatment. n = 3 sets of liver neutrophils pooled from 2∼3 mice. ∗∗P < .01. DAPI, 4′,6-diamidino-2-phenylindole; WT, wild-type.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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