FIGURE

Fig. 16

ID

ZDB-FIG-240130-32

Publication

Mi et al., 2023 - Stimulation of liver fibrosis by N2 neutrophils in Wilson's disease

Other Figures

All Figure Page

Back to All Figure Page

Fig. 16

TGF?1 is highly increased in hepatocytes in ATP7B-KO mice. (A) Formalin-fixed mouse liver tissue sections from SM16-treated or vehicle-treated wild-type and ATP7B-KO mice were subjected to immunofluorescence staining of anti-TGF?1 and anti-albumin. Representative images of TGF?1 (green), albumin (red), and nuclei (blue) are shown. Arrows indicate TGF?1-positive hepatocytes. Scale bar: 40 ?m. (B) qPCR of mRNA levels of Tgf?1 in liver hepatocytes isolated from wild-type and ATP7B-KO mice upon SM16 or vehicle treatment. n = 3 sets of liver hepatocytes pooled from 2?3 mice. ??P < .01. (C) Methylation-specific PCR in Socs3 promoter in liver neutrophils from wild-type and ATP7B-KO mice. Left panel: Representative images of methylation-specific PCR in Socs3 promoter. Right panel: Quantification of band levels by ImageJ. M, methylated; U, unmethylated. n = 3 sets of liver neutrophils pooled from 2?3 mice. ???P < .001. DAPI, 4?,6-diamidino-2-phenylindole; WT, wild-type.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Mol Gastroenterol Hepatol