FIGURE

Figure 6

ID

ZDB-FIG-231115-20

Publication

Li et al., 2023 - Stanniocalcin 1a regulates organismal calcium balance and survival by suppressing Trpv6 expression and inhibiting IGF signaling in zebrafish

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Figure 6

A proposed model. Stc1a plays dual roles in ionocytes. Stc1a suppresses local IGF signaling and inhibits NaR cell proliferation by inhibiting Papp-aa-mediated Igfbp5a degradation. Stc1a also inhibits Trpv6 expression and activities. These two functions are linked. Trpv6-mediated calcium signaling inhibits IGF signaling, while IGF signaling upregulates Trpv6 expression. A loss of Stc1a reactivates IGF-PI3 kinase-Akt-Tor signaling in NaR cells and increased NaR cell proliferation. In addition, Trpv6 expression and Trpv6-mediated calcium uptake in each NaR cell are elevated in the stc1a^-/- mutant fish. These changes contribute to abnormal calcium deposits in the yolk sac region and kidney and to the developemnt of cardiac edema, body swelling, and premature death phenotypes.

Expression Data

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Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)