FIGURE

Figure 5

ID

ZDB-FIG-231115-19

Publication

Li et al., 2023 - Stanniocalcin 1a regulates organismal calcium balance and survival by suppressing Trpv6 expression and inhibiting IGF signaling in zebrafish

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Figure 5

Pharmacological inhibition and double deletion of Trpv6 rescues cardiac edema and body swelling, and delays premature death of stc1a^-/- fish. (A) Loss of Stc1a reduces heartbeat rate. Heartbeat rate stc1a^-/- and siblings was determined and shown. *, P < 0.05. n = 9~17. (B) Gross morphology of fish of the indicated genotypes at the indicated time. Progeny of stc1a^+/- intercrosses were raised in E3 embryo medium and treated with or without 10 μg/L CdCl₂ from 3 dpf until the indicated time. Fish were genotyped individually. Representative views of the indicated genotypes at the indicated stages are shown and survival curve shown in (C). Scale bar = 0.5 mm. P < 0.0001 by log-rank test. (D, E) Gross morphology of fish of the indicated genotypes at the indicated time. Representative views at the indicated stages are shown and survival curve shown in (E). Scale bar = 0.2 mm. P < 0.0001 by log-rank test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	stc1l^mi610/mi610 trpv6^mi604/mi604; stc1l^mi610/mi610
Condition:	chemical treatment by environment: cadmium dichloride
Observed In:	heart contraction whole organism
Stage Range:	Day 4 to Days 7-13

Phenotype Detail

Acknowledgments

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