FIGURE

Fig. 5

ID

ZDB-FIG-231106-36

Publication

Gounou et al., 2023 - Annexin-A5 and annexin-A6 silencing prevents metastasis of breast cancer cells in zebrafish

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Fig. 5

Silencing of ANXA5 and ANXA6 prevents metastasis process of MDA-MB-231 cells in zebrafish. (a,b) Control (a, n = 24) or sgANXA5/A6 MDA-MB-231 (b, n = 24) cells were injected in the perivitelline space of Casper zebrafish embryos. Tumor imaging was done by fluorescence microscopy at 24- and 48-hpi through the tdTomato fluorescent protein constitutively expressed in MDA-MB-231 cells and merged with bright-field images. Insets display magnified images of a portion of the tail and head with metastases (white arrows). (c) The percentage of embryos, either injected by control or sgANXA5/A6 MDA-MB-231 cells, which presented caudal or head metastases was quantified at 24 hpi. Mortality rate was calculated at 48 hpi.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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