FIGURE

Fig. 1

ID

ZDB-FIG-231106-32

Publication

Gounou et al., 2023 - Annexin-A5 and annexin-A6 silencing prevents metastasis of breast cancer cells in zebrafish

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Fig. 1

High ANXA5 or ANXA6 expression in advanced cancer patients is a poor prognosis factor. (a,b) Survival curves from Kaplan?Meier plot profiles for breast (n = 201), gastric (n = 305), lung (n = 70), or ovarian (n = 1220) high-grade and -stage cancer patients, stratified by high (red line) and low expression (black line) of ANXA5 (a) or ANXA6 (b) mRNA (Affymetrix identifier, 200782_at and 200982_s_at, respectively). In each analysis, hazard ratio (HR) and log-rank probability were calculated. A HR significantly different from 1 means that survival was better in one of both groups. For example, if a HR is 1.5, the survival probability in group 1 is 1.5 higher than in group 2. To note, cancer grade (typically numbered from 1 to 3) correlates with the velocity of the disease development while stage (from 1 to 4) characterizes the extent of affected tissues. Advanced cancers were triple-negative subtype, stage 3, stage 3 + grade 4, and stage 3, for breast, lung, ovarian, and gastric cancer, respectively. HR, hazard ratio.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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