FIGURE

Figure 1

ID

ZDB-FIG-230621-46

Publication

Ochi et al., 2020 - CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions

Other Figures

All Figure Page

Back to All Figure Page

Figure 1

CCDC61 Is an Evolutionally Conserved Protein Paralogous to SAS6

(A) Domain architectures of the XRCC4 superfamily members. Low complexity regions are drawn by lines.

(B) A phylogenetic tree of CCDC61 orthologs. Accession numbers of the corresponding amino acid sequences are provided in Table S1. Numbers are bootstrap values.

(C) Crystal structure of hCCDC61¹⁻¹⁴³. The structure is presented using a cartoon representation and a rainbow color scheme from the N terminus (N; blue) to the C terminus (C; red). Missing loops are drawn with dotted lines.

(D) Crystal structures of the XRCC4 superfamily members SAS6, XRCC4, XLF, and PAXX (PDB: 2Y3W [van Breugel et al., 2011], 1IK9 [Sibanda et al., 2001], 2QM4 [Li et al., 2008], and 3WTD [Ochi et al., 2015], respectively).

See also Figures S1, S7 and Table S1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Structure (London, England : 1993), 28, Ochi, T., Quarantotti, V., Lin, H., Jullien, J., Rosa E Silva, I., Boselli, F., Barnabas, D.D., Johnson, C.M., McLaughlin, S.H., Freund, S.M.V., Blackford, A.N., Kimata, Y., Goldstein, R.E., Jackson, S.P., Blundell, T.L., Dutcher, S.K., Gergely, F., van Breugel, M., CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions, 674689.e11674-689.e11, Copyright (2020) with permission from Elsevier. Full text @ Structure