FIGURE

Figure 6

ID

ZDB-FIG-230621-51

Publication

Ochi et al., 2020 - CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions

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Figure 6

Model of the Role of CCDC61 in Ciliary Function (in Chlamydomonas)

CCDC61 localizes to the basal body and forms filaments that bind to centriolar and/or non-centriolar microtubules. This facilitates striated fiber formation and the correct formation of basal body-associated structures, and therefore, results in the correct cilium number. A CCDC61 mutant that does not bind microtubules (MT-binding null mutant) still localizes to the basal body region. However, the mutant is incapable of facilitating striated fiber formation, leads to incorrect formation of basal body-associated structures, and therefore causes abnormal cilium numbers.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Structure (London, England : 1993), 28, Ochi, T., Quarantotti, V., Lin, H., Jullien, J., Rosa E Silva, I., Boselli, F., Barnabas, D.D., Johnson, C.M., McLaughlin, S.H., Freund, S.M.V., Blackford, A.N., Kimata, Y., Goldstein, R.E., Jackson, S.P., Blundell, T.L., Dutcher, S.K., Gergely, F., van Breugel, M., CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions, 674689.e11674-689.e11, Copyright (2020) with permission from Elsevier. Full text @ Structure