ZFIN Image: Ochi et al., 2020, Figure 1

Image

Figure Caption

Figure 1

CCDC61 Is an Evolutionally Conserved Protein Paralogous to SAS6

(A) Domain architectures of the XRCC4 superfamily members. Low complexity regions are drawn by lines.

(B) A phylogenetic tree of CCDC61 orthologs. Accession numbers of the corresponding amino acid sequences are provided in Table S1. Numbers are bootstrap values.

(C) Crystal structure of hCCDC61¹⁻¹⁴³. The structure is presented using a cartoon representation and a rainbow color scheme from the N terminus (N; blue) to the C terminus (C; red). Missing loops are drawn with dotted lines.

(D) Crystal structures of the XRCC4 superfamily members SAS6, XRCC4, XLF, and PAXX (PDB: 2Y3W [van Breugel et al., 2011], 1IK9 [Sibanda et al., 2001], 2QM4 [Li et al., 2008], and 3WTD [Ochi et al., 2015], respectively).

See also Figures S1, S7 and Table S1.

Acknowledgments

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Reprinted from Structure (London, England : 1993), 28, Ochi, T., Quarantotti, V., Lin, H., Jullien, J., Rosa E Silva, I., Boselli, F., Barnabas, D.D., Johnson, C.M., McLaughlin, S.H., Freund, S.M.V., Blackford, A.N., Kimata, Y., Goldstein, R.E., Jackson, S.P., Blundell, T.L., Dutcher, S.K., Gergely, F., van Breugel, M., CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions, 674689.e11674-689.e11, Copyright (2020) with permission from Elsevier. Full text @ Structure