FIGURE

Fig. 7

ID

ZDB-FIG-230315-114

Publication

Zhang et al., 2022 - Deficiency of nde1 in zebrafish induces brain inflammatory responses and autism-like behavior

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Fig. 7

Analysis of brain inflammatory response and behavior of minocycline treated zebrafish

(A) Relative expression level of IL-6, TNF-α, IL-1β, and NF-kb in nde1^+/+, nde1^−/−, and minocycline-treated zebrafish.

(B and C) Locomotor activity (B) and movement trend graph (C) of 3.5 mpf nde1^+/+, nde1^−/−, nde1^+/+ treated with MC, and nde1^−/− treated with MC, n = 12.

(D) Inter-fish distance of four groups of zebrafish in shoaling behavior analysis (n = 10).

(E) Schematic and representative heatmap of social preference test.

Time ratio and distance ratio in the social area were displayed (n = 10). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001. Data are presented as mean ± SEM

Expression Data

Genes:	il1b il6 tnfa
Fish:	TU nde1^{zf3784/zf3784} (TU)
Condition:	chemical treatment by environment: minocycline
Anatomical Term:	brain
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU nde1^{zf3784/zf3784} (TU)
Condition:	chemical treatment by environment: minocycline
Observed In:	brain social behavior swimming behavior
Stage:	Adult

Phenotype Detail

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