FIGURE

Figure 5

ID

ZDB-FIG-221226-284

Publication

Ruzic et al., 2022 - Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological Evaluation

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Figure 5

Changes in cell cycle phase distribution of MDA-MB-231 cells upon treatment with compounds 6b, 7b, 8b, 9b, and tubastatin A. After the 24 h, 48 h, and 72 h continual treatment of MDA-MB-231 cells with investigated compounds at IC₅₀, as well as tubastatin A at IC₅₀ and 20 μM, cells were stained with propidium iodide and analyzed by flow cytometry. White bar—apoptotic cells with DNA content corresponding to sub-G1 fraction; sandy bar—cells with DNA content corresponding to G0/G1 phases; orange bar—cells with DNA content corresponding to S phase; maroon bar—cells with DNA content corresponding to G2/M phases (compared to the untreated control).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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