FIGURE

Figure 4

ID

ZDB-FIG-221226-283

Publication

Ruzic et al., 2022 - Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological Evaluation

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Figure 4

Newly synthesized HDAC inhibitors activate the intrinsic cell death pathway. The proportion of early apoptotic and late apoptotic MDA-MB-231 cells was measured using bivariate Annexin V/7AAD analysis by flow cytometry after the cells underwent treatment with tested compounds at IC₅₀ concentration for (A) 24 h, (B) 48 h, and (C) 72 h. (D) Dissipation of mitochondrial membrane potential was assessed by flow cytometry using JC-1 dye (compared to the untreated control). Significant differences between treatments were determined by t-test: * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001 (compared to the untreated control).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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