FIGURE

Fig. 8

ID

ZDB-FIG-221010-30

Publication

Chen et al., 2021 - A conserved residue in the P2X4 receptor has a nonconserved function in ATP recognition

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Fig. 8

Figure 8. Molecular dynamics (MD) simulations of hP2X3^WT, AmP2X^WT, and their equivalent mutants. A, distance measurements between ATP and P128 during 0.5-μs MD simulations of hP2X3^WT and hP2X3^E109A. B and C, superimpositions of initial open structure and conformations after MD simulations of hP2X3^WT and hP2X3^E109A. The dashed lines indicate the distance between the C_α of P128 and N9 atoms of ATP. D, distance measurements between ATP and I115 during 0.5-μs MD simulations of AmP2X^WT and AmP2X^E129A. E and F, superimpositions of initial open structure and snapshots after MD simulations of AmP2X^WT and AmP2X^E129A. The trajectories were sampled every 200 ps. AmP2X, gulf coast tick (Amblyomma maculatum) P2X; hP2X3, human (Homo sapiens) P2X3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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