FIGURE

Fig. 4

ID

ZDB-FIG-221010-26

Publication

Chen et al., 2021 - A conserved residue in the P2X4 receptor has a nonconserved function in ATP recognition

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Fig. 4

Figure 4. Role of E118 in determining the apparent affinity of rP2X4. A and B, representative current traces (A) and pooled data (B) for WT and rP2X4 mutants. About 8 μM ATP was first applied (gray bars) and then switched to 1 mM ATP (green bars). R values are derived from the ratio of 1 mM ATP-induced current to 8 μM ATP-induced current. Open circles of each scatter represent each measurement through whole-cell recordings, n = 15, 7, 7, 6, 5, 3, and 6, from left to right, respectively. ∗p < 0.05, ∗∗p < 0.01 versus WT, one-way ANOVA with Bonferroni post-test (F(6, 42) = 11.54, p < 0.0001). rP2X4, rat (Rattus norvegicus) P2X4.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Biol. Chem.