ZFIN Image: Chen et al., 2021, Fig. 4

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Figure Caption

Fig. 4

Figure 4. Role of E118 in determining the apparent affinity of rP2X4. A and B, representative current traces (A) and pooled data (B) for WT and rP2X4 mutants. About 8 ?M ATP was first applied (gray bars) and then switched to 1 mM ATP (green bars). R values are derived from the ratio of 1 mM ATP-induced current to 8 ?M ATP-induced current. Open circles of each scatter represent each measurement through whole-cell recordings, n = 15, 7, 7, 6, 5, 3, and 6, from left to right, respectively. ?p < 0.05, ??p < 0.01 versus WT, one-way ANOVA with Bonferroni post-test (F(6, 42) = 11.54, p < 0.0001). rP2X4, rat (Rattus norvegicus) P2X4.

Acknowledgments

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