FIGURE

Figure 3

ID

ZDB-FIG-220515-3

Publication

Xu et al., 2022 - Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish

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Figure 3

Nur77 regulates amino acid metabolism in zebrafish larvae. (A) Heatmaps of transcripts in amino acid metabolism enrichment. Colors represent high (red), low (blue), or average (white) expression values based on Z-score-normalized fragments per kilobase per million mapped read (FPKM) values for each gene. The Z-score indicators are shown under each map. The fold change (log2) is shown on the right. (B) The validation of the expression levels of differentially expressed genes by qRT-PCR analysis in the categories of amino acid metabolism (n = 3). (C) Disturbed valine, leucine, and isoleucine degradation. Blocks represent transcript-encoded enzymes. Green blocks represent downregulated genes, and black blocks represent unchanged genes. (D) Amino acids compositions in WT and nur77^−/− embryos. Results are represented as means with standard errors (n = 3); ^*p < 0.05; ^**p < 0.01; ***p < 0.001, ****p < 0.0001 by t-test.

Expression Data

Genes:	aox5 hadhaa hmgcs1 ldha
Fish:	nr4a1^{xmu201/xmu201} (AB)
Anatomical Term:	whole organism
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nr4a1^{xmu201/xmu201} (AB)
Observed In:	whole organism whole organism alanine whole organism asparagine whole organism glutamic acid whole organism histidine whole organism isoleucine whole organism leucine whole organism lysine whole organism methionine whole organism phenylalanine whole organism proline whole organism serine whole organism tyrosine whole organism valine
Stage:	Day 6

Phenotype Detail

Acknowledgments

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