FIGURE

Fig. 6

ID

ZDB-FIG-220506-7

Publication

Venezia et al., 2021 - Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

PPAR modulation impairs exocrine pancreas length and morphology. A) Exocrine pancreas length was measured in Tg(ptf1a-GFP) transgenic along the nasal-caudal axis. PPARβ/δ antagonist exposure significantly decreased pancreas length, displaying an inverted U-shaped curve, and agonist exposure significantly decreased pancreas length in a concentration dependent manner. Data is presented as boxplots and represents the quantiles for each set of data, and significant p-values are indicated above each plot (p < 0.05). n = 40–45 antagonist, n = 38–47 agonist eleutheroembryos. B) Aberrant pancreatic morphologies observed due to PPAR modulation included curved, wispy, and ectopic exocrine variants. Incidence of aberrant morphologies is presented in Table 2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Tox. App. Pharmacol.