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Fig. 6 PPAR modulation impairs exocrine pancreas length and morphology. A) Exocrine pancreas length was measured in Tg(ptf1a-GFP) transgenic along the nasal-caudal axis. PPARβ/δ antagonist exposure significantly decreased pancreas length, displaying an inverted U-shaped curve, and agonist exposure significantly decreased pancreas length in a concentration dependent manner. Data is presented as boxplots and represents the quantiles for each set of data, and significant p-values are indicated above each plot (p < 0.05). n = 40–45 antagonist, n = 38–47 agonist eleutheroembryos. B) Aberrant pancreatic morphologies observed due to PPAR modulation included curved, wispy, and ectopic exocrine variants. Incidence of aberrant morphologies is presented in Table 2.