FIGURE

Fig. 8

ID

ZDB-FIG-220506-9

Publication

Venezia et al., 2021 - Modulation of PPAR signaling disrupts pancreas development in the zebrafish, Danio rerio

Other Figures

All Figure Page

Back to All Figure Page

Fig. 8

PPAR modulation alters lipid accumulation at 8 dpf. Nile Red plate reader assay was performed to quantify larval lipid accumulation 3 days after discontinuing exposure. All values are normalized to control. (A,B) Larvae exposed to the PPAR? antagonist had decreased neutral lipid accumulation, while those exposed to the agonist were increased. (C) PPAR? antagonist exposure displayed an increasing trend in lipid accumulation, however not significant. Conversely, agonist exposure decreased lipid accumulation. (D) Both PPAR?/? antagonist and agonist exposure significantly decreased lipid accumulation in a concentration dependent manner. Asterisks (*) indicate a difference between designated treatment group and the control (p < 0.05). n = 13?16 biological replicates for PPAR?; n = 7?10 PPAR?/?; n = 10?13 for PPAR?. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Tox. App. Pharmacol.