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FIGURE 7

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ZDB-FIG-220131-456

Publication

Khan et al., 2021 - Carbofuran affects cellular autophagy and developmental senescence through the impairment of Nrf2 signalling

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FIGURE 7

A proposed schematic model of carbofuran induced declines in biological ageing through impairment of Nrf2 signalling. Carbofuran exposure induces oxidative stress through ROS generation. At low to the medium stress conditions, cells protect themselves via Nrf2-mediated transactivation of antioxidant regulatory genes as well as through epigenetic modification. Persistent carbofuran exposure increases oxidative stress, under which the cellular protective mechanism falls and impair the Nrf2 signalling. Ultimately, the suppression of the Nrf2 signalling induces cellular senescence and affects biological ageing

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell. Mol. Med.