FIGURE

FIGURE 5

ID

ZDB-FIG-220131-454

Publication

Khan et al., 2021 - Carbofuran affects cellular autophagy and developmental senescence through the impairment of Nrf2 signalling

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FIGURE 5

Carbofuran exposure for a short duration of time up-regulates both Gstp1 (This is fine, no change!) and autophagosomal LC3 expressions. (A) The gross expressions of gstp1-EGFP and mCherry-LC3 in transgenic zebrafish. Carbofuran treatment for a short duration of time (56 to 60 hpf) significantly increased both gstp1-EGFP and autophagosomal mCherry-LC3 expressions throughout the fish. Scale bar: 250 μm. (B) Cellular gstp1-GFP and mCherry-LC3 expressions (head region, dorsal to the eye) under the confocal microscope. Like gross observation, carbofuran treatment significantly increased both cellular gstp1-EGFP and autophagosomal mCherry-LC3 expressions. Scale bar: 10 μm. The number of animals was 8 (n = 8). Data are presented as mean ± SE. *P ≤ .05; **P ≤.01; ***P ≤ .005

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell. Mol. Med.