FIGURE

FIGURE 4

ID

ZDB-FIG-220131-453

Publication

Khan et al., 2021 - Carbofuran affects cellular autophagy and developmental senescence through the impairment of Nrf2 signalling

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FIGURE 4

Carbofuran down-regulates Gstp1 (This is fine, no change!) expression and up-regulates autophagosomal LC3 expression. (A) The gross expressions of gstp1-EGFP and mCherry-LC3 in transgenic zebrafish under macro-microscope. Transgenic zebrafish were exposed to carbofuran for 12 hours (48 to 60 hpf). Carbofuran treatment significantly declined gstp1-EGFP expression and significantly increased autophagosomal mCherry-LC3 expression throughout the fish. Scale bar: 250 μm. (B) Cellular gstp1-EGFP and mCherry-LC3 expressions (head region, dorsal to the eye) under the confocal microscope. Like gross observation, carbofuran treatment significantly declined cellular gstp1-EGFP expression and significantly increased autophagosomal mCherry-LC3 expression. Scale bar: 10 μm. The number of animals was 8 (n = 8). Data are presented as mean ± SE. **P ≤ .01; ***P ≤ .005

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell. Mol. Med.