FIGURE

Fig. 8

ID

ZDB-FIG-211116-8

Publication

Ghaddar et al., 2021 - Deleterious Effects of Overfeeding on Brain Homeostasis and Plasticity in Adult Zebrafish

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Fig. 8

Switch from an overfeeding diet to a standard diet partially restores normal metabolic parameters and brain homeostasis. (A) Fasting blood glucose measurements at week 6 in CTRL and ?DIO Reversible? fish (n?=?10). (B, C) Graphs showing dot-blot quantification of peripheral AGE and 4-HNE levels (tail) of CTRL and ?DIO Reversible? fish at week 6 (n?=?4). (D) Graph showing dot-blot quantification of 4-HNE levels in the brain of CTRL and ?DIO Reversible? fish at week 6 (n?=?4, p?=?0.051). (E) Representative dorsal (first row) and ventral (second row) view pictures of CTRL and ?DIO Reversible? fish brains after Evans blue intraperitoneal injection at week 6 (n?=?3). (F) Hypothalamic vibratome section showing no striking difference in Evans blue staining between CTRL and ?DIO Reversible? fish (Red). (G, H) Statistical analysis of the PCNA-positive area in CTRL and ?DIO Reversible? zebrafish in the ventral telencephalon (Vv Vd) and in the telencephalic region (Dm+Vv Vd; n?=?3), showing no statistical difference in proliferation between groups. Bar graph: SEM. Student's t-test: **p?

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Antibody Labeling

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Acknowledgments

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