FIGURE

Fig 3

ID

ZDB-FIG-211018-19

Publication

Karim et al., 2021 - Heterodimer-heterotetramer formation mediates enhanced sensor activity in a biophysical model for BMP signaling

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Fig 3

Heterodimer-heterotetramer prevalence under different conditions.

A. Shows the distributions of the complexes as a function of ligand concentration in a system with excess Acvr1. The level of BmpR1 receptor complexes exceeds the level of Bmp2/7-Acvr1-BmpR1-(Type II)₂ except for a narrow band from ~.4nM to 1 nM. B. The weakest possible Acvr1 –Bmp2/7 binding affinity in which Bmp2/7-Acvr1-BmpR1-(Type II)2 is the most prevalent receptor tetramer at a ligand concentration of 0.1 nM. Recall that higher K_D (nM) indicates weaker binding affinity. C-D. Same as A and B with higher amounts of Type II receptor in the model. E. In the Bmp2/7-only system with 10nM type II receptor, 9-fold excess Acvr1 leads to greater heterodimer-heterotetramer complex formation over a wide range of ligand concentration.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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