ZFIN Image: Karim et al., 2021, Fig 3

Image

Figure Caption

Fig 3 Heterodimer-heterotetramer prevalence under different conditions.

A. Shows the distributions of the complexes as a function of ligand concentration in a system with excess Acvr1. The level of BmpR1 receptor complexes exceeds the level of Bmp2/7-Acvr1-BmpR1-(Type II)₂ except for a narrow band from ~.4nM to 1 nM. B. The weakest possible Acvr1 –Bmp2/7 binding affinity in which Bmp2/7-Acvr1-BmpR1-(Type II)2 is the most prevalent receptor tetramer at a ligand concentration of 0.1 nM. Recall that higher K_D (nM) indicates weaker binding affinity. C-D. Same as A and B with higher amounts of Type II receptor in the model. E. In the Bmp2/7-only system with 10nM type II receptor, 9-fold excess Acvr1 leads to greater heterodimer-heterotetramer complex formation over a wide range of ligand concentration.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Comput. Biol.