FIGURE

Fig. 1

ID

ZDB-FIG-211018-17

Publication

Karim et al., 2021 - Heterodimer-heterotetramer formation mediates enhanced sensor activity in a biophysical model for BMP signaling

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

BMP ligand receptor interactions and oligomerization network.

A. Cartoon depiction of ‘overhead view’ of BMP ligand-dimer receptor-tetramer complexes. BMP signaling occurs through an oligomeric signaling complex which necessarily consists of a ligand dimer (red/gold plus) bound to a receptor tetramer. The receptor tetramer requires two Type II receptors (green square) and two Type I receptors (BmpR1 in purple and/or Acvr1 in cyan). The heterodimer-heterotetramer is underlined in red. B. Network of BMP ligand-receptor interactions. Oligomeric signaling complexes are formed through reversible reactions (double-sided arrows). Tetrameric complexes are underlined in the figure above. The heterodimer-heterotetramer, Bmp2/7-Acvr1-BmpR1-(Type II)₂ is double underlined.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Comput. Biol.