ZFIN Image: Karim et al., 2021, Fig. 1

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Figure Caption

Fig. 1 BMP ligand receptor interactions and oligomerization network.

A. Cartoon depiction of ‘overhead view’ of BMP ligand-dimer receptor-tetramer complexes. BMP signaling occurs through an oligomeric signaling complex which necessarily consists of a ligand dimer (red/gold plus) bound to a receptor tetramer. The receptor tetramer requires two Type II receptors (green square) and two Type I receptors (BmpR1 in purple and/or Acvr1 in cyan). The heterodimer-heterotetramer is underlined in red. B. Network of BMP ligand-receptor interactions. Oligomeric signaling complexes are formed through reversible reactions (double-sided arrows). Tetrameric complexes are underlined in the figure above. The heterodimer-heterotetramer, Bmp2/7-Acvr1-BmpR1-(Type II)₂ is double underlined.

Acknowledgments

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