FIGURE

Fig. 7

ID

ZDB-FIG-211007-13

Publication

Conedera et al., 2021 - The TGFβ/Notch axis facilitates Müller cell-to-epithelial transition to ultimately form a chronic glial scar

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Fig. 7

Pharmacological Notch inhibition (DAPT) increases TGFβ3 expression. (A-D) Analysis of TGFβ pathway during MC injury response in DAPT treated mice at different time points (Day 1, 3 and 7). Detection of TGFβ1 (A.i-A.iii), TGFβ2 (B.i-B.iii), TGFβ3 (C.i-C.iii) and p-Smad3 (D.i-D.iii) in GS⁺ MCs. Shown are representative sections stained for GS (red), TGFβ1/2/3 and p-Smad3 (green). (A.iv, B.iv, C.iv, D.iv) Histograms illustrating the mean ± SD of the number of TGFβ1, TGFβ2 and TGFβ3⁺ cells normalized by the total number of GS+ cells expressed in percentage (n = 12). INL, inner nuclear layer; ONL, outer nuclear layer. Scale bar of all images equals 50 μm. (E) Schematic summary of molecular outcomes of DAPT treatment in murine MCs

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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