FIGURE

FIGURE 4

ID

ZDB-FIG-210817-25

Publication

Lin et al., 2021 - Base editing-mediated perturbation of endogenous PKM1/2 splicing facilitates isoform-specific functional analysis in vitro and in vivo

Other Figures

All Figure Page

Back to All Figure Page

FIGURE 4

PKM/E10‐GT mutation inhibits cell proliferation and related gene expression. A, E10‐GT mutation inhibits cell growth. CCK‐8 kit was used to analyse the cell growth of single‐clone‐derived E10‐GT‐mutant cells and wild‐type HCT116 cells served as a control. Absorbance was measured at OD450 at 0, 48 and 96 h. B, RNA‐seq analysis of differentially expressed genes in E10‐GT‐mutant cells relative to wild‐type HCT116 cells. Representative differentially expressed genes were also presented. c‐d. GO C, and KEGG D, pathway analysis of the differentially expressed genes responding to E10‐GT mutation

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Prolif.