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ZIRC
ZFIN ID: ZDB-GENE-040816-1
Gene Name: cadherin 5
Gene Symbol: cdh5    Nomenclature History

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Previous Names: cadherin 5, type 2, VE-cadherin (vascular epithelium), fc88a07, mlb, vascular endothelial cadherin (1), vecdn (1), wu:fc88a07 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have several functions, including cadherin binding activity; calcium ion binding activity; and protein homodimerization activity. Involved in circulatory system development; negative regulation of angiogenesis; and unidimensional cell growth. Predicted to localize to the catenin complex; cell surface; and cell-cell adherens junction. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; intermediate cell mass of mesoderm; lateral mesoderm; and nervous system. Orthologous to human CDH5 (cadherin 5).
Genome Resources: Alliance (1),  Gene:445471 (1),  Ensembl(GRCz11):ENSDARG00000075549 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bw306 Point Mutation Exon 3 Premature Stop ENU
hsi8 Complex Unknown Unknown CRISPR
sa7601 Point Mutation Unknown Missense ENU
sa10732 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21048 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21049 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34151 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38634 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40984 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ubs8 Small Deletion Exon 3 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
    ubs9 Small Deletion Unknown Unknown ZINC_FINGER_NUCLEASE
    ubs25 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cdh5 1
    CRISPR2-cdh5
    1
    CRISPR3-cdh5
    1
    CRISPR4-cdh5 1
    MO1-cdh5 N/A 8
    MO2-cdh5 N/A 5
    MO3-cdh5 N/A 2
    MO5-cdh5 N/A 2
    MO6-cdh5 N/A 2
    MO7-cdh5 N/A 1
    MO8-cdh5 N/A 1
    TALEN1-cdh5
    1
    DISEASE ASSOCIATED WITH cdh5 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cdh5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell adhesion involved in sprouting angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 32)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdh5-201 (1)    Ensembl 6772
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cdh5 Rabbit IHC, WB 24
    Ab2-cdh5 polyclonal Rabbit WB SDIX
    1
    CONSTRUCTS WITH SEQUENCES FROM cdh5
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(5xUAS:cdh5-EGFP) UAS cdh5EGFP Danio rerio 1 11
    TgBAC(cdh5:cdh5-TFP-TENS-Venus) cdh5 cdh5TENSTFPVenus Danio rerio 1 2
    TgBAC(cdh5:Citrine) cdh5 Citrine Danio rerio 1 2
    TgBAC(cdh5:GAL4FF) cdh5 GAL4FF Danio rerio 1 12
    MARKER RELATIONSHIPS
    cdh5 Contained in: [Fosmid] CH1073-220I8 (1) (order this)
    cdh5 Encodes: [EST] fc88a07
    [cDNA] MGC:194987 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001003983 (1) 3102 bp
    Genomic GenBank:CU464121 (1) 77238 bp
    Select Tool
    Polypeptide UniProtKB:B3DJF6 (1) 767 aa
    Sequence Clusters UniGene:118013 (1)
    Sequence Information (all 21)
    ORTHOLOGY for cdh5 ( Chr: 7 )
    CITATIONS (186)