Gene
cdh5
- ID
- ZDB-GENE-040816-1
- Name
- cadherin 5
- Symbol
- cdh5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable beta-catenin binding activity; cadherin binding activity; and protein phosphatase binding activity. Acts upstream of or within with a positive effect on cell-cell junction organization. Acts upstream of or within circulatory system development; negative regulation of angiogenesis; and unidimensional cell growth. Located in cell-cell junction. Is expressed in several structures, including angioblastic mesenchymal cell; brain; cardiovascular system; eye; and mesoderm. Orthologous to human CDH5 (cadherin 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 134 figures from 99 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 28 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bw306 | Allele with one point mutation | Exon 3 | Premature Stop | ENU | |
| cqu2Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| hsi8 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| sa7601 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa10732 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21048 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21049 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34151 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38634 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40984 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cdh5 | Prykhozhij et al., 2018 | |
| CRISPR2-cdh5 | Charlton-Perkins et al., 2019 | |
| CRISPR3-cdh5 | Charlton-Perkins et al., 2019 | |
| CRISPR4-cdh5 | Paatero et al., 2018 | |
| CRISPR5-cdh5 | Wen et al., 2021 | |
| MO1-cdh5 | N/A | (10) |
| MO2-cdh5 | N/A | (5) |
| MO3-cdh5 | N/A | (2) |
| MO5-cdh5 | N/A | (2) |
| MO6-cdh5 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Cadherin, Y-type LIR-motif | Catenin binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q68SP4 | InterPro | 767 |
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(cdh5:Citrine) |
|
| 1 | (3) | |
| TgBAC(cdh5:GAL4FF) |
|
| 1 | (22) | |
| Tg(5xUAS:cdh5-EGFP) |
|
| 1 | (12) | |
| TgBAC(cdh5:cdh5-mClavGR2) |
|
|
| 1 | Yin et al., 2024 |
| TgBAC(cdh5:cdh5-TFP-TENS-Venus) |
|
| 1 | (14) | |
| Tg(cdh5:GAL4-VP16) |
|
| 1 | Quillien et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-220I8 | ZFIN Curated Data | |
| Encodes | EST | fc88a07 | ||
| Encodes | cDNA | MGC:194987 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003983 (1) | 3102 nt | ||
| Genomic | GenBank:CU464121 (1) | 77238 nt | ||
| Polypeptide | UniProtKB:Q68SP4 (1) | 767 aa |
- Anzell, A.R., Kunz, A.B., Donovan, J.P., Tran, T.G., Lu, X., Young, S., Roman, B.L. (2024) Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity. Angiogenesis. 27(3):501-522
- Bowley, G., Irving, S., Hoefer, I., Wilkinson, R., Pasterkamp, G., Darwish, H.M.S., White, S., Francis, S.E., Chico, T., Noel, E., Serbanovic-Canic, J., Evans, P.C. (2024) Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Scientific Reports. 14:3013030130
- Dong, Y., Yang, Y., Wang, H., Feng, D., Nist, E., Yapundich, N., Spurlock, B., Craft, M., Qian, L., Liu, J. (2024) Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells. Science advances. 10:eadk4694
- Guo, J., Lin, K., Wang, S., He, X., Huang, Z., Zheng, M. (2024) Effects and mechanisms of Porphyromonas gingivalis outer membrane vesicles induced cardiovascular injury. BMC oral health. 24:112112
- Huang, W., Yue, Y., Hao, W., Zhang, Z., Cai, P., Yang, D. (2024) mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish. Stem Cell Reports. 19(9):1277-1288
- Lee, J., Goeckel, M.E., Levitas, A., Colijn, S., Shin, J., Hindes, A., Mun, G., Burton, Z., Chintalapati, B., Yin, Y., Abello, J., Solnica-Krezel, L., Stratman, A. (2024) CXCR3-CXCL11 Signaling Restricts Angiogenesis and Promotes Pericyte Recruitment. Arteriosclerosis, Thrombosis, and Vascular Biology. 44(12):2577-2595
- Ranjan, G., Sehgal, P., Scaria, V., Sivasubbu, S. (2024) SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function. EMBO reports. 25(11):4950-4978
- Wang, X., Zhao, J., Xu, J., Li, B., Liu, X., Xie, G., Duan, X., Liu, D. (2024) Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal. eLIFE. 13:
- Yin, J., Schellinx, N., Maggi, L., Gundel, K., Wiesner, C., Kotini, M.P., Lee, M., Phng, L.K., Belting, H.G., Affolter, M. (2024) Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1. Nature communications. 15:97149714
- Canham, L., Sendac, S., Diagbouga, M.R., Wolodimeroff, E., Pirri, D., Tardajos Ayllon, B., Feng, S., Souilhol, C., Chico, T.J.A., Evans, P.C., Serbanovic-Canic, J. (2023) EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy. Arteriosclerosis, Thrombosis, and Vascular Biology. 43(4):547-561
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