FIGURE

Figure 6

ID

ZDB-FIG-210310-101

Publication

García-González et al., 2021 - Behavioral Effects of Developmental Exposure to JWH-018 in Wild-Type and Disrupted in Schizophrenia 1 (disc1) Mutant Zebrafish

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Figure 6

(A) Forced light/dark test in 5 dpf wild-type and disc1 loss-function mutant larvae. Sample sizes for each group: control disc1 +/+: n = 39, THC disc1 +/+: n = 29, control disc1 +/–: n = 41, THC disc1 +/–: n = 45, control disc1 –/–: n = 40, THC disc1 –/–: n = 29. Each dot represents mean distance travelled per minute. Error bars represent ± SEM. (B,C) One-second resolution plots of the transitions from dark to light during the forced light/dark test. Each dot represents mean distance travelled per second. (D) Response and habituation to startle stimuli test in 6 dpf control and THC-treated wild-type and disc1 mutant larvae. Sample sizes: control disc1 +/+: n = 36, THC disc1 +/+: n = 35, control disc1 +/–: n = 36, THC disc1 +/–: n = 35, control disc1 –/–: n = 36, THC disc1 –/–: n = 36.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT disc1^fh291/fh291 disc1^fh291/+
Conditions:	chemical treatment by environment: Delta(9)-tetrahydrocannabinol altered light dark cycle, chemical treatment by environment: Delta(9)-tetrahydrocannabinol
Observed In:	response to light stimulus swimming
Stage:	Day 5

Phenotype Detail

Acknowledgments

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