FIGURE

Figure 6—figure supplement 1.

ID

ZDB-FIG-210113-141

Publication

Wague et al., 2020 - Mechanistic insights into volatile anesthetic modulation of K2P channels

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Figure 6—figure supplement 1.

Additional molecular dynamics simulation data.

(A) Distance of the center of geometry of the isoflurane ligand from the center of the spherical restraint, of radius 7A, as a function of simulation time during TREK1 wildtype (WT) + isoflurane trajectory 2 (B) C-alpha limited per residue RMSD within the TREK1 TM2/TM3 loop from TREK1 WT + isoflurane trajectory 1 (black symbols) or trajectory 2 (gray symbols), as compared with the final frame of the equilibrated TREK1 WT-free simulation. (C) Pi-stacking plots, as described in the Figure 6 legend, for the F185/F214 residue interaction in the unliganded neighboring TREK1 subunit. (D) Side chain χ ₁ and χ ₂ dihedral angle residence plots for mTREK1 I189 during the TREK1 WT-free (top) and TREK1 WT + isoflurane simulation trajectories (middle, bottom).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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