FIGURE

Figure 7

ID

ZDB-FIG-201003-55

Publication

Knuth et al., 2020 - Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish

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Figure 7

Evaluating INS signaling in VDD liver and AT. (A,B) VDD fish had significantly elevated expression of insig1, insig2, with a significant decrease in cidec in liver 6 mpf, indicating sustained INS signaling contrary to also having significantly elevated expression of cish, socs2, and socs3b, suppressors of cytokine signaling thought to shut down the INS signaling cascade. (C) Downregulation of insig1 and cidec in VDD AT 6 mpf.

Expression Data

Genes:	cidec insig1 insig2 insrb irs2b socs1a socs2 socs3b
Fish:	AB
Condition:	nutrient decreased
Anatomical Terms:	adipose tissue liver
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	nutrient decreased
Observed In:	adipose tissue liver
Stage:	Adult

Phenotype Detail

Acknowledgments

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